Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disrupting G6PD-mediated Redox homeostasis enhances chemosensitivity in colorectal cancer

10 Jul 2017

Abstract excerpt

Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme that generates NADPH to maintain reduced glutathione (GSH), which scavenges reactive oxygen species (ROS) to protect cancer cell from oxidative damage. In this study, we mainly investigate the potential roles of G6PD in colorectal cancer (CRC) development and chemoresistance. We discover that G6PD is overexpressed in CRC cells and patient specimens. High...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Heme Oxygenase-1 and Carbon Monoxide
Share to Neonatal Health and Biochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28692052
DOI: 10.1038/onc.2017.227

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disrupting G6PD-mediated Redox homeostasis enhances chemosensitivity in colorectal cancerPMID 28692052Read ↗

Synergistic Antitumor Activity of SUMO1 degrader and Oxaliplatin through G6PD Inhibition in Colorectal CancerSemantic proximity Read ↗

Exploring the role of glucose‑6‑phosphate dehydrogenase in cancer (Review).Semantic proximity Read ↗

The Redox Role of G6PD in Cell Growth, Cell Death, and CancerSemantic proximity Read ↗

Glucose-6-phosphate Dehydrogenase: a Biomarker and Potential Therapeutic Target for CancerSemantic proximity Read ↗

The Emerging Roles of the Metabolic Regulator G6PD in Human CancersSemantic proximity Read ↗

Glucose-6-phosphate Dehydrogenase (G6PD): the Role in Tumor Progression and ImmunotherapySemantic proximity Read ↗

Integrative analyses of gene expression and chemosensitivity of patient-derived ovarian cancer spheroids link G6PD-driven redox metabolism to cisplatin chemoresistanceSemantic proximity Read ↗

The Role of Oxidative Stress and Its Counteractive Utility in Colorectal Cancer (CRC)Semantic proximity Read ↗

FTO promotes colorectal cancer progression and chemotherapy resistance via demethylating G6PD/PARP1Semantic proximity Read ↗

A New G6PD Knockdown Tumor-Cell Line with Reduced Proliferation and Increased Susceptibility to Oxidative StressSemantic proximity Read ↗

Reactive oxygen species in colorectal cancer: The therapeutic impact and its potential roles in tumor progression via perturbation of cellular and physiological dysregulated pathwaysSemantic proximity Read ↗

Redox Regulation of Stem-like Cells Though the CD44v-xCT Axis in Colorectal Cancer: Mechanisms and Therapeutic ImplicationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.