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Article

Exploring the effects of polymorphisms on cis-regulatory signal transduction response.

Trends in molecular medicine - 1 Feb 2013

MacKenzie Alasdair, Hing Benjamin, Davidson Scott

Abstract excerpt

cis-Regulatory sequences (CRSs) direct cell-specific and inducible gene expression in response to signal transduction networks, and it is becoming apparent that many cases of disease susceptibility and drug response stratification are due to polymorphisms that alter CRS responses in a context-dependent manner. In the current review, we describe successful methods for identifying CRSs and analyzing the effects of...

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Share to Epigenomics
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 23265842
DOI: 10.1016/j.molmed.2012.11.003
PMCID: PMC3569712

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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