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Article

Enhanced eMAGE applied to identify genetic factors of nuclear hormone receptor dysfunction via combinatorial gene editing.

Nature communications - 18 Jun 2024

Ciaccia Peter N, Liang Zhuobin, Schweitzer Anabel Y, Metzner Eli, Isaacs Farren J

Abstract excerpt

Technologies that generate precise combinatorial genome modifications are well suited to dissect the polygenic basis of complex phenotypes and engineer synthetic genomes. Genome modifications with engineered nucleases can lead to undesirable repair outcomes through imprecise homology-directed repair, requiring non-cleavable gene editing strategies. Eukaryotic multiplex genome engineering (eMAGE) generates precise...

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Identifiers

PMID: 38890276
DOI: 10.1038/s41467-024-49365-z
PMCID: PMC11189492

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