Article
Functional footprinting of regulatory DNA.
Nature methods - 1 Oct 2015
Vierstra Jeff, Reik Andreas, Chang Kai-Hsin, Stehling-Sun Sandra, Zhou Yuanyue, Hinkley Sarah J, Paschon David E, Zhang Lei, Psatha Nikoletta, Bendana Yuri R, O'Neil Colleen M, Song Alexander H, Mich Andrea K, Liu Pei-Qi, Lee Gary, Bauer Daniel E, Holmes Michael C, Orkin Stuart H, Papayannopoulou Thalia, Stamatoyannopoulos George, Rebar Edward J, Gregory Philip D, Urnov Fyodor D, Stamatoyannopoulos John A
Abstract excerpt
Regulatory regions harbor multiple transcription factor (TF) recognition sites; however, the contribution of individual sites to regulatory function remains challenging to define. We describe an approach that exploits the error-prone nature of genome editing-induced double-strand break repair to...
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