Article

A novel map of human p53 response elements uncovers evidence of selection pressures and variants similar to Li-Fraumeni Syndrome mutations

2022-09-29

Abstract excerpt

<h4>Background</h4> The advent of functional genomic techniques and next generation sequencing has improved the characterization of the non-protein coding regions of the genome. However, the integration of these data into clinical practice is still in its infancy. Fifty percent of cancers mutate TP53 , which promotes tumorigenesis, in part, by inhibiting its ability to bind to non-coding regions of the genome and...

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Literature Corpus work: 7ea45d81-745a-5053-afd9-e91cd217001a
DOI: 10.1101/2022.09.28.22280453

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