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Article

Negative regulation of cytokine signaling and immune responses by SOCS proteins.

1 Jan 2005

Abstract excerpt

Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological functions through JAKs (Janus tyrosine kinases) and STAT (signal transduction and activators of transcription) transcription factors. CIS (cytokine-inducible SH2 (Src homology 2) protein) and SOCS (suppressor of cytokine signaling) are a family of...

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PMID: 15899058
DOI: 10.1186/ar1741

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