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The ScCas9++ variant expands the CRISPR toolbox for genome editing in plants

19 Aug 2021

Abstract excerpt

Abstract The development of clustered regularly interspaced palindromic repeats (CRISPR)‐associated protein (Cas) variants with a broader recognition scope is critical for further improvement of CRISPR/Cas systems. The original Cas9 protein from Streptococcus canis (ScCas9) can recognize simple NNG‐protospacer adjacent motif (PAM) targets, and therefore possesses a broader range relative to current CRISPR/Cas...

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PMID: 34411422
DOI: 10.1111/jipb.13164

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