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Article

nkx3.2 mutant zebrafish accommodate jaw joint loss through a phenocopy of the head shapes of Paleozoic jawless fish.

The Journal of experimental biology - 5 Aug 2020

Miyashita Tetsuto, Baddam Pranidhi, Smeeton Joanna, Oel A Phil, Natarajan Natasha, Gordon Brogan, Palmer A Richard, Crump J Gage, Graf Daniel, Allison W Ted

Abstract excerpt

The vertebrate jaw is a versatile feeding apparatus. To function, it requires a joint between the upper and lower jaws, so jaw joint defects are often highly disruptive and difficult to study. To describe the consequences of jaw joint dysfunction, we engineered two independent null alleles of a single jaw joint marker gene, nkx3.2, in zebrafish. These mutations caused zebrafish to become functionally jawless via...

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PMID: 32527964
DOI: 10.1242/jeb.216945
PMCID: PMC10668335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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