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Article

Zebrafish model for spondylo-megaepiphyseal-metaphyseal dysplasia reveals post-embryonic roles of Nkx3.2 in the skeleton.

Development (Cambridge, England) - 25 Jan 2021

Smeeton Joanna, Natarajan Natasha, Naveen Kumar Arati, Miyashita Tetsuto, Baddam Pranidhi, Fabian Peter, Graf Daniel, Crump J Gage

Abstract excerpt

The regulated expansion of chondrocytes within growth plates and joints ensures proper skeletal development through adulthood. Mutations in the transcription factor NKX3.2 underlie spondylo-megaepiphyseal-metaphyseal dysplasia (SMMD), which is characterized by skeletal defects including scoliosis, large epiphyses, wide growth plates and supernumerary distal limb joints. Whereas nkx3.2 knockdown zebrafish and...

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PMID: 33462117
DOI: 10.1242/dev.193409
PMCID: PMC7860120

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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