Article
An intronic variant in OPRD1 predicts treatment outcome for opioid dependence in African-Americans.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Sept 2013
Crist Richard C, Clarke Toni-Kim, Ang Alfonso, Ambrose-Lanci Lisa M, Lohoff Falk W, Saxon Andrew J, Ling Walter, Hillhouse Maureen P, Bruce R Douglas, Woody George, Berrettini Wade H
Abstract excerpt
Although buprenorphine and methadone are both effective treatments for opioid dependence, their efficacy can vary significantly among patients. Genetic differences may explain some of the variability in treatment outcome. Understanding the interactions between genetic background and pharmacotherapy may result in more informed treatment decisions. This study is a pharmacogenetic analysis of the effects of genetic...
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