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Inactivation of Transcriptional Regulator FabT Influences Colony Phase Variation of Streptococcus pneumoniae.

mBio - 31 Aug 2021

Zhang Jinghui, Ye Weijie, Wu Kaifeng, Xiao Shengnan, Zheng Yuqiang, Shu Zhaoche, Yin Yibing, Zhang Xuemei

Abstract excerpt

Streptococcus pneumoniae is an opportunistic pathogen that can alter its cell surface phenotype in response to the host environment. We demonstrated that the transcriptional regulator FabT is an indirect regulator of capsular polysaccharide, an important virulence factor of Streptococcus pneumoniae. Transcriptome analysis between the wild-type D39s and D39ΔfabT mutant strains unexpectedly identified a...

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Identifiers

PMID: 34399624
DOI: 10.1128/mBio.01304-21
PMCID: PMC8406281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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