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Article

Epigenetic Switch Driven by DNA Inversions Dictates Phase Variation in Streptococcus pneumoniae.

PLoS pathogens - 1 Jul 2016

Li Jing, Li Jing-Wen, Feng Zhixing, Wang Juanjuan, An Haoran, Liu Yanni, Wang Yang, Wang Kailing, Zhang Xuegong, Miao Zhun, Liang Wenbo, Sebra Robert, Wang Guilin, Wang Wen-Ching, Zhang Jing-Ren

Abstract excerpt

DNA methylation is an important epigenetic mechanism for phenotypic diversification in all forms of life. We previously described remarkable cell-to-cell heterogeneity in epigenetic pattern within a clonal population of Streptococcus pneumoniae, a leading human pathogen. We here report that the epigenetic diversity is caused by extensive DNA inversions among hsdSA, hsdSB, and hsdSC, three methyltransferase hsdS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Restriction-Modification Enzymes

Share to Epigenesis, Genetic

Share to Mice, Inbred C57BL

Share to Mutagenesis, Site-Directed

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Source

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Identifiers

PMID: 27427949
DOI: 10.1371/journal.ppat.1005762
PMCID: PMC4948785

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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