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A random six-phase switch regulates pneumococcal virulence via global epigenetic changes

30 Sept 2014

Abstract excerpt

Streptococcus pneumoniae (the pneumococcus) is the world's foremost bacterial pathogen in both morbidity and mortality. Switching between phenotypic forms (or 'phases') that favour asymptomatic carriage or invasive disease was first reported in 1933. Here, we show that the underlying mechanism for such phase variation consists of genetic rearrangements in a Type I restriction-modification system (SpnD39III). The...

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PMID: 25268848
DOI: 10.1038/ncomms6055

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