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Article

Effects of the ERES pathogenicity region regulator Ralp3 on Streptococcus pyogenes serotype M49 virulence factor expression.

Journal of bacteriology - 1 Jul 2012

Siemens Nikolai, Fiedler Tomas, Normann Jana, Klein Johannes, Münch Richard, Patenge Nadja, Kreikemeyer Bernd

Abstract excerpt

Streptococcus pyogenes (group A streptococcus [GAS]) is a highly virulent Gram-positive bacterium. For successful infection, GAS expresses many virulence factors, which are clustered together with transcriptional regulators in distinct genomic regions. Ralp3 is a central regulator of the ERES region. In this study, we investigated the role of Ralp3 in GAS M49 pathogenesis. The inactivation of Ralp3 resulted in...

Topics

Bacterial Adhesion
Bacterial Proteins
Cell Line, Tumor
Gene Expression Profiling
Gene Expression Regulation, Bacterial
Humans
Hyaluronic Acid
Mutation
Phenotype
RNA, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Streptococcus pyogenes

Transcriptome

Virulence

Virulence Factors

Source

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Identifiers

PMID: 22544273
DOI: 10.1128/JB.00227-12
PMCID: PMC3393516

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