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Article

Effects of the ERES pathogenicity region regulator Ralp3 on Streptococcus pyogenes serotype M49 virulence factor expression.

Journal of bacteriology - 1 Jul 2012

Siemens Nikolai, Fiedler Tomas, Normann Jana, Klein Johannes, Münch Richard, Patenge Nadja, Kreikemeyer Bernd

Abstract excerpt

Streptococcus pyogenes (group A streptococcus [GAS]) is a highly virulent Gram-positive bacterium. For successful infection, GAS expresses many virulence factors, which are clustered together with transcriptional regulators in distinct genomic regions. Ralp3 is a central regulator of the ERES region. In this study, we investigated the role of Ralp3 in GAS M49 pathogenesis. The inactivation of Ralp3 resulted in...

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Identifiers

PMID: 22544273
DOI: 10.1128/JB.00227-12
PMCID: PMC3393516

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