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A phasevarion controls multiple virulence traits, including expression of vaccine candidates, in <i>Streptococcus pneumoniae</i>

2022-02-09

Abstract excerpt

Streptococcus pneumoniae is the most common cause of bacterial illness worldwide. Current vaccines based on the polysaccharide capsule (PCV-13 and PPSV-23) are only effective against a limited number of the >100 capsular serotypes. A universal vaccine based on conserved protein antigens requires a thorough understanding of gene expression in S. pneumoniae. Restriction-Modification (R-M) systems, classically descr...

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Identifiers and source

Literature Corpus work
8fa44a72-3ad7-557a-8de7-eefdbe5d188e
DOI
10.1101/2022.02.08.479631
Open publication

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