Article
A single charge in the actin binding domain of fascin can independently tune the linear and non-linear response of an actin bundle network.
The European physical journal. E, Soft matter - 1 May 2015
Maier M, Müller K W, Heussinger C, Köhler S, Wall W A, Bausch A R, Lieleg O
Abstract excerpt
Actin binding proteins (ABPs) not only set the structure of actin filament assemblies but also mediate the frequency-dependent viscoelastic moduli of cross-linked and bundled actin networks. Point mutations in the actin binding domain of those ABPs can tune the association and dissociation dynamics of the actin/ABP bond and thus modulate the network mechanics both in the linear and non-linear response regime. We...
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