Article
D-Loop Mutation G42A/G46A Decreases Actin Dynamics.
Biomolecules - 8 May 2020
Matsuzaki Mizuki, Fujiwara Ikuko, Kashima Sae, Matsumoto Tomoharu, Oda Toshiro, Hayashi Masahito, Maeda Kayo, Takiguchi Kingo, Maéda Yuichiro, Narita Akihiro
Abstract excerpt
Depolymerization and polymerization of the actin filament are indispensable in eukaryotes. The DNase I binding loop (D-loop), which forms part of the interface between the subunits in the actin filament, is an intrinsically disordered loop with a large degree of conformational freedom. Introduction of the double mutation G42A/G46A to the D-loop of the beta cytoskeletal mammalian actin restricted D-loop...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.