Article
X-chromosome inactivation: molecular mechanisms from the human perspective.
Human genetics - 1 Aug 2011
Yang Christine, Chapman Andrew G, Kelsey Angela D, Minks Jakub, Cotton Allison M, Brown Carolyn J
Abstract excerpt
X-chromosome inactivation is an epigenetic process whereby one X chromosome is silenced in mammalian female cells. Since it was first proposed by Lyon in 1961, mouse models have been valuable tools to uncover the molecular mechanisms underlying X inactivation. However, there are also inherent differences between mouse and human X inactivation, ranging from sequence content of the X inactivation center to the...
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