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Article

Hybrid Stomach-Intestinal Chromatin States Underlie Human Barrett's Metaplasia.

Gastroenterology - 1 Sept 2021

Singh Harshabad, Ha Kyungsik, Hornick Jason L, Madha Shariq, Cejas Paloma, Jajoo Kunal, Singh Pratik, Polak Paz, Lee Hwajin, Shivdasani Ramesh A

Abstract excerpt

BACKGROUND & AIMS: Tissue metaplasia is uncommon in adults because established cis-element programs resist rewiring. In Barrett's esophagus, the distal esophageal mucosa acquires a predominantly intestinal character, with notable gastric features, and is predisposed to developing invasive cancers. We sought to understand the chromatin underpinnings of Barrett's metaplasia and why it commonly displays simultaneous...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34090884
DOI: 10.1053/j.gastro.2021.05.057
PMCID: PMC8380686

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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