Article

Polyclonal and clonal organoid models of Barrett oesophagus and oesophageal adenocarcinoma reveal heterogeneity in progression and therapy response

2026-01-09

Abstract excerpt

Oesophageal adenocarcinoma (OAC) is a major cause of morbidity and mortality. OAC and its precursor, Barrett oesophagus (BO), are defined by substantial early heterogeneity, complicating prevention and treatment of OAC and remaining poorly recapitulated by current in vitro and animal model systems. We have generated 116 patient- and healthy donor- derived organoids (PDOs) spanning normal oesophagogastric tissue, B...

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Literature Corpus work: ab0af229-7f81-5284-b5b4-11868856a636
DOI: 10.64898/2026.01.09.698383

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