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Article

Connection of core and tail Mediator modules restrains transcription from TFIID-dependent promoters.

PLoS genetics - 1 Aug 2021

Saleh Moustafa M, Jeronimo Célia, Robert François, Zentner Gabriel E

Abstract excerpt

The Mediator coactivator complex is divided into four modules: head, middle, tail, and kinase. Deletion of the architectural subunit Med16 separates core Mediator (cMed), comprising the head, middle, and scaffold (Med14), from the tail. However, the direct global effects of tail/cMed disconnection are unclear. We find that rapid depletion of Med16 downregulates genes that require the SAGA complex for full...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34383744
DOI: 10.1371/journal.pgen.1009529
PMCID: PMC8384189

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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