Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure of mammalian Mediator complex reveals Tail module architecture and interaction with a conserved core.

Nature communications - 1 Mar 2021

Zhao Haiyan, Young Natalie, Kalchschmidt Jens, Lieberman Jenna, El Khattabi Laila, Casellas Rafael, Asturias Francisco J

Abstract excerpt

The Mediator complex plays an essential and multi-faceted role in regulation of RNA polymerase II transcription in all eukaryotes. Structural analysis of yeast Mediator has provided an understanding of the conserved core of the complex and its interaction with RNA polymerase II but failed to reveal the structure of the Tail module that contains most subunits targeted by activators and repressors. Here we present...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Conserved Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease

Share to Mammals

Share to Mediator Complex

Share to Protein Structure, Secondary

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 33649303
DOI: 10.1038/s41467-021-21601-w
PMCID: PMC7921410

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure of mammalian Mediator complex reveals Tail module architecture and interaction with a conserved core.PMID 33649303Read ↗

The Mediator Complex: Progress over the Past DecadeSemantic proximity Read ↗

Structure of human Mediator-RNA polymerase II transcription pre-initiation complexSemantic proximity Read ↗

Core Mediator structure at 3.4 Å extends model of transcription initiation complex.Semantic proximity Read ↗

Mediator-RNA Polymerase II Interactions Critical for Transcriptional Activation Are Mediated by the N-terminal Half of MED14 and C-terminal Domain of RPB1Semantic proximity Read ↗

Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization.Semantic proximity Read ↗

The tail-module of yeast Mediator complex is required for telomere heterochromatin maintenance.Semantic proximity Read ↗

Direct interaction of RNA polymerase II and mediator required for transcription in vivo.Semantic proximity Read ↗

Functional interplay between Mediator and TFIIB in preinitiation complex assembly in relation to promoter architecture.Semantic proximity Read ↗

Structural basis of the human transcriptional Mediator complex modulated by its dissociable Kinase moduleSemantic proximity Read ↗

Functional interplay between Mediator and RSC chromatin remodeling complex controls nucleosome-depleted region maintenance at promotersSemantic proximity Read ↗

Proteomic Interactome of C. elegans Mediator Complex Subunit 28 (MDT-28) Reveals Predominant Association with a Restricted Set of Core Mediator Subunits and an Affinity to Additional Structural and Enzymatic Proteins.Semantic proximity Read ↗

Mediator independently orchestrates multiple steps of preinitiation complex assembly in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.