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Article

Functional studies of the yeast med5, med15 and med16 mediator tail subunits.

PloS one - 1 Jan 2013

Larsson Miriam, Uvell Hanna, Sandström Jenny, Rydén Patrik, Selth Luke A, Björklund Stefan

Abstract excerpt

The yeast Mediator complex can be divided into three modules, designated Head, Middle and Tail. Tail comprises the Med2, Med3, Med5, Med15 and Med16 protein subunits, which are all encoded by genes that are individually non-essential for viability. In cells lacking Med16, Tail is displaced from Head and Middle. However, inactivation of MED5/MED15 and MED15/MED16 are synthetically lethal, indicating that Tail...

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Source

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Identifiers

PMID: 23991176
DOI: 10.1371/journal.pone.0073137
PMCID: PMC3750046

Genes

MED15
MED16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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