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Article

Histone modifications influence mediator interactions with chromatin.

Nucleic acids research - 1 Oct 2011

Zhu Xuefeng, Zhang Yongqiang, Bjornsdottir Gudrun, Liu Zhongle, Quan Amy, Costanzo Michael, Dávila López Marcela, Westholm Jakub Orzechowski, Ronne Hans, Boone Charles, Gustafsson Claes M, Myers Lawrence C

Abstract excerpt

The Mediator complex transmits activation signals from DNA bound transcription factors to the core transcription machinery. Genome wide localization studies have demonstrated that Mediator occupancy not only correlates with high levels of transcription, but that the complex also is present at transcriptionally silenced locations. We provide evidence that Mediator localization is guided by an interaction with...

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Identifiers

PMID: 21742760
DOI: 10.1093/nar/gkr551
PMCID: PMC3201872

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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