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Influence of Killer Immunoglobulin-Like Receptors and Somatic Mutations on Transplant Outcomes in Acute Myeloid Leukemia.

Transplantation and cellular therapy - 1 Nov 2021

Hong Sanghee, Rybicki Lisa, Zhang Aiwen, Thomas Dawn, Kerr Cassandra M, Durrani Jibran, Rainey Magdalena A, Mian Agrima, Behera Tapas R, Carraway Hetty E, Nazha Aziz, Mukherjee Sudipto, Advani Anjali S, Patel Bhumika, Kalaycio Matt, Bolwell Brian J, Hanna Rabi, Gerds Aaron T, Pohlman Brad, Hamilton Betty K, Sekeres Mikkael A, Majhail Navneet S, Maciejewski Jaroslaw P, Askar Medhat, Sobecks Ronald

Abstract excerpt

Natural killer (NK) cells are regulated by killer immunoglobulin-like receptor (KIR) interactions with human leukocyte antigen class I ligands. Various models of NK cell alloreactivity have been associated with outcomes after allogeneic hematopoietic cell transplant (alloHCT), but results have varied widely. We hypothesized that somatic mutations in acute myeloid leukemia (AML) in the context of KIR profiles may...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 34380091
DOI: 10.1016/j.jtct.2021.08.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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