Impact of KIR and HLA Genotypes on Outcomes after Reduced-Intensity Conditioning Hematopoietic Cell Transplantation.

doi:10.1016/j.bbmt.2015.05.002

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Article

Impact of KIR and HLA Genotypes on Outcomes after Reduced-Intensity Conditioning Hematopoietic Cell Transplantation.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Sept 2015

Sobecks Ronald M, Wang Tao, Askar Medhat, Gallagher Meighan M, Haagenson Michael, Spellman Stephen, Fernandez-Vina Marcelo, Malmberg Karl-Johan, Müller Carlheinz, Battiwalla Minoo, Gajewski James, Verneris Michael R, Ringdén Olle, Marino Susana, Davies Stella, Dehn Jason, Bornhäuser Martin, Inamoto Yoshihiro, Woolfrey Ann, Shaw Peter, Pollack Marilyn, Weisdorf Daniel, Milller Jeffrey, Hurley Carolyn, Lee Stephanie J, Hsu Katharine

Abstract excerpt

Natural killer cells are regulated by killer cell immunoglobulin-like receptor (KIR) interactions with HLA class I ligands. Several models of natural killer cell reactivity have been associated with improved outcomes after myeloablative allogeneic hematopoietic cell transplantation (HCT), but this issue has not been rigorously addressed in reduced-intensity conditioning (RIC) unrelated donor (URD) HCT. We studied...

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Identifiers

PMID: 25960307
DOI: 10.1016/j.bbmt.2015.05.002
PMCID: PMC4537837

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