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Article

Allelic Polymorphisms of KIRs and HLAs Predict Favorable Responses to Tyrosine Kinase Inhibitors in CML.

Cancer immunology research - 1 Jun 2018

Ureshino Hiroshi, Shindo Takero, Kojima Hiroto, Kusunoki Yasushi, Miyazaki Yuki, Tanaka Hidenori, Saji Hiroh, Kawaguchi Atsushi, Kimura Shinya

Abstract excerpt

Response to tyrosine kinase inhibitors (TKIs) is variable in chronic myeloid leukemia (CML), and elevated natural killer (NK) cells during TKI therapy are positively correlated with superior outcomes. NK cell function involves interactions of their killer immunoglobulin-like receptors (KIRs) and human leukocyte antigen (HLA) class I on target cells, and the avidity of KIR-HLA interactions depends on the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29695383
DOI: 10.1158/2326-6066.CIR-17-0462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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