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Article

Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jun 2010

Cuevas-Ramos Gabriel, Petit Claude R, Marcq Ingrid, Boury Michèle, Oswald Eric, Nougayrède Jean-Philippe

Abstract excerpt

Escherichia coli is a normal inhabitant of the human gut. However, E. coli strains of phylogenetic group B2 harbor a genomic island called "pks" that codes for the production of a polyketide-peptide genotoxin, Colibactin. Here we report that in vivo infection with E. coli harboring the pks island...

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Identifiers

PMID: 20534522
DOI: 10.1073/pnas.1001261107
PMCID: PMC2895108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20534522-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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