Article
RIT1 Drives Oncogenic Transformation and Is an Actionable Target in Lung Adenocarcinoma.
Cancer research - 2 Sept 2025
Mozzarelli Alessandro M, Cuevas-Navarro Antonio, Shuldiner Emily G, Vega Martha, Chatila Walid K, Xu Jierui, Walch Henry S, Niu Yuzhe, Petrov Dmitri A, Schultz Nikolaus, Urisman Anatoly, Rudin Charles M, Winslow Monte M, Castel Pau
Abstract excerpt
RIT1 is a small GTPase of the RAS family, and RIT1 mutations have been identified in lung cancer, leukemia, and the developmental disorder Noonan syndrome. Mutations in RIT1 lead to increased protein levels due to impaired proteolysis, resulting in dysregulation of RAS/MAPK signaling and other pathways. In this study, we documented the diversity of RIT1 mutations in human lung cancer and showed that physiologic...
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