Article

Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state

2024-11-12

Abstract excerpt

<h4>ABSTRACT</h4> The discovery of oncogene addiction in cancer has led to the development of over a dozen FDA-approved biomarker-driven therapies in lung adenocarcinoma. Somatic mutations of the “Ras-like in all tissues” (RIT1) gene are non-canonical driver events in lung cancer, occurring in ∼2% of lung adenocarcinomas in a mutually exclusive fashion with KRAS and EGFR mutations. Patients with RIT1 -mutant l...

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Literature Corpus work: 261219e9-e3d3-5cb2-b6fe-13e7b96b1527
DOI: 10.1101/2024.11.11.623044

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