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Article

Oncogenic RIT1 mutations confer ferroptosis vulnerability in lung adenocarcinoma.

Biology direct - 7 Feb 2025

Ma Ruilan, Yang Dian, Wang Peng, Zhang Ziyi, Zhang Xuehong, Song Jialiang, Liu Han, Liu Shuyan, Zhang Yingqiu, Zou Lijuan

Abstract excerpt

Members from the RAS GTPase superfamily have been closely implicated in the tumorigenesis of various human cancers. Recent sequencing analysis of lung adenocarcinoma has revealed the prevalence of alterations in the RIT1 gene that is a close RAS paralog. However, relative to RAS subfamily members KRAS, NRAS, and HRAS, our characterization of RIT1 oncogenic properties remains incomplete. Therefore, further...

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Share to Adenocarcinoma of Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39920793
DOI: 10.1186/s13062-025-00613-2
PMCID: PMC11804091

Genes

RIT1
E2F1
HRAS
KRAS
NFE2L2
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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