Article
Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state.
Cell reports - 28 Oct 2025
Rominger Mary C, O'Brien Siobhan, Gupta Saksham, Moorthi Sitapriya, McSharry Maria, Kamlapurkar Shriya, Lowe Amy R, Waldum Annie, Lo April, Duke Fujiko, Wu Feinan, Headley Mark B, Cromwell Elizabeth, Glabman Raisa, Koehne Amanda, Berger Alice H
Abstract excerpt
Mutations in "Ras-like in all tissues" (RIT1) occur in up to 2% of lung adenocarcinomas and are mutually exclusive with KRAS and EGFR mutations, suggesting that RIT1 may act as a non-canonical driver oncogene in lung cancer. However, the lack of a RIT1-mutant lung cancer model has hindered the development and testing of RIT1-targeted therapeutics. Here, we report a mouse model with conditional regulation of the...
Read the complete abstract on PubMedTopics
- Animals
- Lung Neoplasms
- YAP-Signaling Proteins
- Mice
- ras Proteins
- Humans