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Methods to Characterize Mutant Spectra of RNA Viruses: The Case of SARS-CoV-2.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2026

Perales Celia, Soria María Eugenia, de Ávila Ana Isabel, Martínez-González Brenda, Gallego Isabel, García-Crespo Carlos, Somovilla Pilar, Mínguez Pablo, Gadea Ignacio, Domingo Esteban

Abstract excerpt

Viral isolates consist of complex mixtures of many variants that are termed mutant spectra, distributions, clouds or swarms. They include information on virus behavior that is not captured by consensus sequences. Here, we describe experimental procedures, a bioinformatics pipeline, and calculations to characterize the mutant spectrum of RNA viruses. The data are obtained through the high-resolution MiSeq Illumina...

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PMID: 42056692
DOI: 10.1007/978-1-0716-4836-0_8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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