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Article

The ageing genome, clonal mosaicism and chronic disease.

Current opinion in genetics & development - 1 Feb 2017

Machiela Mitchell J, Chanock Stephen J

Abstract excerpt

Clonal mosaicism arises when a postzygotic mutational event is detectable in subpopulations of cells as an alternative genotype while not present in the germline genome. Although described in a subset of pediatric disorders, new genomic technologies have detected higher than anticipated frequencies of clonal mosaicism in adult population studies, stimulating investigation as to how clonal mosaicism could...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28068559
DOI: 10.1016/j.gde.2016.12.002
PMCID: PMC5446794

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