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Article

Investigating somatic aneuploidy in the brain: why we need a new model.

Chromosoma - 1 Jun 2017

Rosenkrantz Jimi L, Carbone Lucia

Abstract excerpt

The steady occurrence of DNA mutations is a key source for evolution, generating the genomic variation in the population upon which natural selection acts. Mutations driving evolution have to occur in the oocytes and sperm in order to be transmitted to the next generation. Through similar mechanisms, mutations also accumulate in somatic cells (e.g., skin cells, neurons, lymphocytes) during development and adult...

Topics

Aneuploidy
Animals
Brain
Brain Diseases
Humans
Models, Genetic
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 27638401
DOI: 10.1007/s00412-016-0615-4
PMCID: PMC5908214

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