Article
Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans.
American journal of human genetics - 4 Feb 2016
Schick Ursula M, Jain Deepti, Hodonsky Chani J, Morrison Jean V, Davis James P, Brown Lisa, Sofer Tamar, Conomos Matthew P, Schurmann Claudia, McHugh Caitlin P, Nelson Sarah C, Vadlamudi Swarooparani, Stilp Adrienne, Plantinga Anna, Baier Leslie, Bien Stephanie A, Gogarten Stephanie M, Laurie Cecelia A, Taylor Kent D, Liu Yongmei, Auer Paul L, Franceschini Nora, Szpiro Adam, Rice Ken, Kerr Kathleen F, Rotter Jerome I, Hanson Robert L, Papanicolaou George, Rich Stephen S, Loos Ruth J F, Browning Brian L, Browning Sharon R, Weir Bruce S, Laurie Cathy C, Mohlke Karen L, North Kari E, Thornton Timothy A, Reiner Alex P
Abstract excerpt
Platelets play an essential role in hemostasis and thrombosis. We performed a genome-wide association study of platelet count in 12,491 participants of the Hispanic Community Health Study/Study of Latinos by using a mixed-model method that accounts for admixture and family relationships. We discovered and replicated associations with five genes (ACTN1, ETV7, GABBR1-MOG, MEF2C, and ZBTB9-BAK1). Our strongest...
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