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Gene expression and splicing QTL analysis of blood cells in African American participants from the Jackson Heart Study.

Genetics - 4 Sept 2024

Wen Jia, Sun Quan, Huang Le, Zhou Lingbo, Doyle Margaret F, Ekunwe Lynette, Durda Peter, Olson Nels C, Reiner Alexander P, Li Yun, Raffield Laura M

Abstract excerpt

Most gene expression and alternative splicing quantitative trait loci (eQTL/sQTL) studies have been biased toward European ancestry individuals. Here, we performed eQTL and sQTL analyses using TOPMed whole-genome sequencing-derived genotype data and RNA-sequencing data from stored peripheral blood mononuclear cells in 1,012 African American participants from the Jackson Heart Study (JHS). At a false discovery...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39056362
DOI: 10.1093/genetics/iyae098
PMCID: PMC11373511

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