Genome‐wide survey and phylogenetic analysis of histone acetyltransferases and histone deacetylases of Plasmodium falciparum

Abstract excerpt

Malaria parasites can readily sense and adapt to environmental changes, thus making the control and eradication of this disease difficult. Molecular studies have unraveled a very tightly coordinated transcriptional machinery governed by complex regulatory mechanisms including chromatin modification and spatiotemporal compartmentalization. Histone modifying enzymes play key roles in the regulation of chromatin...