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Article

Emerging Chikungunya Virus Variants at the E1-E1 Interglycoprotein Spike Interface Impact Virus Attachment and Inflammation.

Journal of virology - 23 Feb 2022

Rangel Margarita V, McAllister Nicole, Dancel-Manning Kristen, Noval Maria G, Silva Laurie A, Stapleford Kenneth A

Abstract excerpt

Chikungunya virus (CHIKV) is a reemerging arthropod-borne alphavirus and a serious threat to human health. Therefore, efforts toward elucidating how this virus causes disease and the molecular mechanisms underlying steps of the viral replication cycle are crucial. Using an in vivo transmission system that allows intrahost evolution, we identified an emerging CHIKV variant carrying a mutation in the E1...

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Identifiers

PMID: 34935436
DOI: 10.1128/JVI.01586-21
PMCID: PMC8865554

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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