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Article

Informed mutation of western equine encephalitis virus to heparan sulfate binding: Implications for rational design of alphavirus live attenuated vaccines.

PLoS pathogens - 1 Feb 2026

Lukash Tetyana, Poudyal Shishir, Gilliland Theron C, Klose Thomas, Sun Chengqun, Vasilatos Shauna N, Farren Jessica L, Lam Long Kwan Metthew, Kuhn Richard J, Klimstra William B

Abstract excerpt

Encephalitogenic alphaviruses are mosquito-borne viruses that can cause fatal disease in humans and equines. Currently, there are no licensed vaccines or antiviral treatments for these infections. Western equine encephalitis virus (WEEV) is a member of this group that had not produced a human infection in over a decade. However, an outbreak of WEEV encephalitis in humans and equines was reported recently in South...

Topics

Animals
Heparan Sulfate
Encephalitis Virus, Western Equine
Vaccines, Attenuated
Viral Vaccines
Viral Envelope Proteins
Mutation
Mice
Encephalomyelitis, Equine
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 41662398
DOI: 10.1371/journal.ppat.1013941
PMCID: PMC12912690

Genes

VLDLR
PCDH10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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