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Article

Informed mutation of western equine encephalitis virus to heparan sulfate binding: Implications for rational design of alphavirus live attenuated vaccines.

PLoS pathogens - 1 Feb 2026

Lukash Tetyana, Poudyal Shishir, Gilliland Theron C, Klose Thomas, Sun Chengqun, Vasilatos Shauna N, Farren Jessica L, Lam Long Kwan Metthew, Kuhn Richard J, Klimstra William B

Abstract excerpt

Encephalitogenic alphaviruses are mosquito-borne viruses that can cause fatal disease in humans and equines. Currently, there are no licensed vaccines or antiviral treatments for these infections. Western equine encephalitis virus (WEEV) is a member of this group that had not produced a human infection in over a decade. However, an outbreak of WEEV encephalitis in humans and equines was reported recently in South...

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Identifiers

PMID: 41662398
DOI: 10.1371/journal.ppat.1013941
PMCID: PMC12912690

Genes

VLDLR
PCDH10

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