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Cross-serotype protection against group A Streptococcal infections induced by immunization with SPy_2191

15 Jul 2020

Abstract excerpt

Group A Streptococcus (GAS) infection causes a range of diseases, but vaccine development is hampered by the high number of serotypes. Here, using reverse vaccinology the authors identify SPy_2191 as a cross-protective vaccine candidate. From 18 initially identified surface proteins, only SPy_2191 is conserved, surface-exposed and inhibits both GAS adhesion and invasion. SPy_2191 immunization in mice generates...

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PMID: 32669564
DOI: 10.1038/s41467-020-17299-x

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