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Article

The M protein of group A Streptococcus is a key virulence factor and a clinically relevant strain identification marker

1 Sept 2011

Abstract excerpt

The M protein coats group A streptococci (GAS) and acts as the primary antigen and determinant of type-specific immunity. M is essential for GAS virulence, providing antiphagocytic functions critical to survival in human tissues and fluids. Specific regions of M protein also serve as shared antigens, and cross-reactivity between these epitopes and human proteins may be the source of autoimmune sequelae such as...

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PMID: 21852752
DOI: 10.4161/viru.2.5.16342

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