Article

A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein protects against infection

2021-03-02

Abstract excerpt

Group A streptococci have evolved multiple strategies to evade human antibodies, making it challenging to create effective vaccines or antibody treatments. Here, we have generated antibodies derived from the memory B cells of an individual who had successfully cleared a group A streptococcal infection. The antibodies bind with high affinity in the central region of the surface-bound M protein. Such antibodies are...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a1c57b10-e1dd-52ad-a549-d904e870d1b8
DOI: 10.1101/2021.03.01.433494

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein protects against infectionDOI 10.1101/2021.03.01.433494Read

A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein mediates immune functionSemantic proximity Read

Group A streptococci induce stronger M protein-fibronectin interaction when specific human antibodies are boundSemantic proximity Read

Human protective response induced by meningococcus B vaccine is mediated by the synergy of multiple bactericidal epitopesSemantic proximity Read

The human antibody repertoire to infectious agents: implications for disease pathogenesis.Semantic proximity Read

Group A Streptococcal S Protein Utilizes Red Blood Cells as Immune Camouflage and Is a Critical Determinant for Immune EvasionSemantic proximity Read

Agnostic B cell selection approach identifies antibodies against K. pneumoniae that synergistically drive complement activation.Semantic proximity Read

Dissecting human antibody responses: useful, basic and surprising findings.Semantic proximity Read

B cell superantigens: a microbe's answer to innate-like B cells and natural antibodies.Semantic proximity Read

Design of Broadly Cross-Reactive M Protein–Based Group A Streptococcal VaccinesSemantic proximity Read

50 Years of structural immunologySemantic proximity Read

The hinge-engineered IgG1-IgG3 hybrid subclass IgGh47 potently enhances Fc-mediated function of anti-streptococcal and SARS-CoV-2 antibodiesSemantic proximity Read

A Primer for Junior Trainees: The Structure, Binding, and Therapeutic Applications of Immunoglobulin GSemantic proximity Read