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Article

Updated model of group A Streptococcus M proteins based on a comprehensive worldwide study.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 May 2013

McMillan D J, Drèze P-A, Vu T, Bessen D E, Guglielmini J, Steer A C, Carapetis J R, Van Melderen L, Sriprakash K S, Smeesters P R

Abstract excerpt

Group A Streptococcus (GAS) M protein is an important virulence factor and potential vaccine antigen, and constitutes the basis for strain typing (emm-typing). Although >200 emm-types are characterized, structural data were obtained from only a limited number of emm-types. We aim to evaluate the sequence diversity of near-full-length M proteins from worldwide sources and analyse their structure, sequence...

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Identifiers

PMID: 23464795
DOI: 10.1111/1469-0691.12134
PMCID: PMC4568957

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