Reverse and structural vaccinology approach to design a highly immunogenic multi-epitope subunit vaccine against Streptococcus pneumoniae infection.

doi:10.1016/j.meegid.2020.104473

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Article

Reverse and structural vaccinology approach to design a highly immunogenic multi-epitope subunit vaccine against Streptococcus pneumoniae infection.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Nov 2020

Mamede Lohany Dias, de Paula Keila Gonçalves, de Oliveira Bianca, Dos Santos Janete Soares Coelho, Cunha Lucas Maciel, Junior Moacyr Comar, Jung Lenice Roteia Cardoso, Taranto Alex Gutterres, de Oliveira Lopes Débora, Leclercq Sophie Yvette

Abstract excerpt

Streptococcus pneumoniae is a pathogen that resides in the upper respiratory tract of healthy individuals, maintaining a commensal relationship with its host. However, the virulent form may be the etiology of pneumonia, meningitis, bacteremia, and other respiratory tract infections. Streptococcal diseases are preventable by vaccination; but currently available vaccines have some drawbacks, especially due to the...

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PMID: 32712314
DOI: 10.1016/j.meegid.2020.104473

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