Rational design of a meningococcal antigen inducing broad protective immunity.

doi:10.1126/scitranslmed.3002234

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Article

Rational design of a meningococcal antigen inducing broad protective immunity.

Science translational medicine - 13 Jul 2011

Scarselli Maria, Aricò Beatrice, Brunelli Brunella, Savino Silvana, Di Marcello Federica, Palumbo Emmanuelle, Veggi Daniele, Ciucchi Laura, Cartocci Elena, Bottomley Matthew James, Malito Enrico, Lo Surdo Paola, Comanducci Maurizio, Giuliani Marzia Monica, Cantini Francesca, Dragonetti Sara, Colaprico Annalisa, Doro Francesco, Giannetti Patrizia, Pallaoro Michele, Brogioni Barbara, Tontini Marta, Hilleringmann Markus, Nardi-Dei Vincenzo, Banci Lucia, Pizza Mariagrazia, Rappuoli Rino

Abstract excerpt

The sequence variability of protective antigens is a major challenge to the development of vaccines. For Neisseria meningitidis, the bacterial pathogen that causes meningitis, the amino acid sequence of the protective antigen factor H binding protein (fHBP) has more than 300 variations. These sequence differences can be classified into three distinct groups of antigenic variants that do not induce...

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PMID: 21753121
DOI: 10.1126/scitranslmed.3002234

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