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Article

Association of the PINX1 Variant rs6984094, Which Lengthens Telomeres, with Systemic Lupus Erythematosus Susceptibility in Chinese Populations.

Journal of immunology research - 1 Jan 2021

Qi Yuan-Yuan, Liu Xin-Ran, He Ying-Xin, Zhou Min, Ning Xiang-Hui, Zhai Ya-Ling, Zhang Xiao-Xue, Wang Xiao-Yang, Zhao Ya-Fei, Cui Yan, Zhao Zhan-Zheng

Abstract excerpt

A recent genome-wide association study (GWAS) of Asian ancestry reported that single nucleotide polymorphism (SNP) in TERT (telomerase reverse transcriptase) was associated with systemic lupus erythematosus (SLE). TERT has a critical role in maintaining the chromosomal stability and the length of telomere. Given that only a small portion of the genetic heritability of SLE has been explained so far, we aimed to...

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Identifiers

PMID: 34337078
DOI: 10.1155/2021/7079359
PMCID: PMC8294968

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