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Article

Genetic variants in telomere-maintenance genes and bladder cancer risk.

PloS one - 1 Jan 2012

Chang Joshua, Dinney Colin P, Huang Maosheng, Wu Xifeng, Gu Jian

Abstract excerpt

Telomeres are critical in maintaining genomic stability. Genetic variants in telomere pathway genes may affect telomere and telomerase function, and subsequently cancer risk. We evaluated 126 SNPs from 10 genes related to telomere regulation in relation to bladder cancer risk. Five SNPs, 4 from TEP1 gene and 1 from PINX1 gene, were found to be highly significant (P<0.01). Out of these, the most significant...

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Share to Epistasis, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Share to Telomere Homeostasis

Share to Urinary Bladder Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 22363464
DOI: 10.1371/journal.pone.0030665
PMCID: PMC3281862

Genes

TEP1
PINX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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