Article
Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus.
Arthritis and rheumatism - 1 Nov 2012
Adrianto Indra, Wang Shaofeng, Wiley Graham B, Lessard Christopher J, Kelly Jennifer A, Adler Adam J, Glenn Stuart B, Williams Adrienne H, Ziegler Julie T, Comeau Mary E, Marion Miranda C, Wakeland Benjamin E, Liang Chaoying, Kaufman Kenneth M, Guthridge Joel M, Alarcón-Riquelme Marta E, Alarcón Graciela S, Anaya Juan-Manuel, Bae Sang-Cheol, Kim Jae-Hoon, Joo Young Bin, Boackle Susan A, Brown Elizabeth E, Petri Michelle A, Ramsey-Goldman Rosalind, Reveille John D, Vilá Luis M, Criswell Lindsey A, Edberg Jeffrey C, Freedman Barry I, Gilkeson Gary S, Jacob Chaim O, James Judith A, Kamen Diane L, Kimberly Robert P, Martín Javier, Merrill Joan T, Niewold Timothy B, Pons-Estel Bernardo A, Scofield R Hal, Stevens Anne M, Tsao Betty P, Vyse Timothy J, Langefeld Carl D, Harley John B, Wakeland Edward K, Moser Kathy L, Montgomery Courtney G, Gaffney Patrick M
Abstract excerpt
OBJECTIVE: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production and altered type I interferon expression. Genetic surveys and genome-wide association studies have identified >30 SLE susceptibility genes. One of these genes, TNIP1, encodes the ABIN1 protein. ABIN1 functions in the immune system by restricting NF-κB signaling. The present study was undertaken to...
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