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Article

Small-molecule compounds boost genome-editing efficiency of cytosine base editor.

Nucleic acids research - 7 Sept 2021

Zhao Tianyuan, Li Qing, Zhou Chenchen, Lv Xiujuan, Liu Hongyan, Tu Tianxiang, Tang Na, Cheng Yanbo, Liu Xiaoyu, Liu Changbao, Zhao Junzhao, Song Zongming, Wang Haoyi, Li Jinsong, Gu Feng

Abstract excerpt

Cytosine base editor (CBE) enables targeted C-to-T conversions at single base-pair resolution and thus has potential therapeutic applications in humans. However, the low efficiency of the system limits practical use of this approach. We reported a high-throughput human cells-based reporter system that can be harnessed for quickly measuring editing activity of CBE. Screening of 1813 small-molecule compounds...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34329468
DOI: 10.1093/nar/gkab645
PMCID: PMC8421147

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